On 18 January 2010, the Major Archbishop of the Syro-Malabar Church, Mar Varkey Cardinal Vithayathil, by his decree (Prot. No. 55/2010) dated 18 January 2010 erected a new eparchy by name Mandya, bifurcating the eparchy of Mananthavady. The new eparchy comprises the four civil districts of Karnataka, namely, Mandya, Hassan, Mysore and Chamarajnagar and has its See in the city of Mandya in the civil district of Mandya. Before the erection of the eparchy of Mandya, the District of Mandya was entrusted to the pastoral care of the Missionary Society of St. Thomas the Apostle (MST) and the District of Hassan, to the Carmelites of Mary Immaculate (CMI). The Districts of Mysore and Chamrajnagar were under the direct pastoral care of the eparchy of Mananthavady. Considering the great distance from the eparchial headquarters of Mananthavady, the geographical, linguistic and cultural differences and the differences in the nature of the apostolates undertaken, there were repeated request by the Local Ordinaries to form a separate eparchy in the region of Mandya.

The XVII Synod of Bishops of the Syro-Malabar Church held in August 2008 consented to the proposal and having obtained the assent of the Holy Father in accordance with CCEO c. 85 §1, the new eparchy of Mandya was erected on 18 January 2010. By another decree of the Major Archbishop, Prot. No. 56/2010 with the same date, Mgr. George Njaralakatt, a priest of the eparchy of Mananthavady and who was at that time working as the Vicar General of the eparchy of Bhadravathi was appointed the first bishop of the new eparchy of Mandya. The new eparchy is a suffragan eparchy of the Archeparchy of Tellicherry. Infant Jesus Church, Henkel is the cathedral of the new eparchy and the Episcopal residence is at Kalenahalli, 6 kms away from the city of Mandya.

The Episcopal Ordination of the Bishop and the Enthronement took place on 7 April 2010 at Henkal along with the official inauguration of the Eparchy. The newly erected diocese of Mandya has an area of 17,460 sq. kms with a total population of 44,47,312 of which around 1300 are Catholics. There are 26 parishes and mission stations looked after by 38 priests belonging to the MST and CMI Congregation a few belonging to the eparchial clergy. There are 5 houses of men religious belonging to 4 religious congregations, 79 religious sisters belonging to 5 religious congregations in 20 convents doing ministry in various fields of the apostolate.